Macromolecular crowding
نویسندگان
چکیده
منابع مشابه
Macromolecular crowding
Although you were born and educated in the USA, you've worked in the UK for over 11 years. What are your views on the different ways science is done in the two countries? I've probably been away from the States too long to judge! One thing that does stand out, however, is the difference in postgraduate (PhD) education and training. Most students in the UK get funding for a three-year PhD after ...
متن کاملMacromolecular crowding: obvious but underappreciated.
Biological macromolecules evolve and function within intracellular environments that are crowded with other macromolecules. Crowding results in surprisingly large quantitative effects on both the rates and the equilibria of interactions involving macromolecules, but such interactions are commonly studied outside the cell in uncrowded buffers. The addition of high concentrations of natural and s...
متن کاملMacromolecular crowding explains overflow metabolism in cells
Overflow metabolism is a metabolic phenotype of cells characterized by mixed oxidative phosphorylation (OxPhos) and fermentative glycolysis in the presence of oxygen. Recently, it was proposed that a combination of a protein allocation constraint and a higher proteome fraction cost of energy generation by OxPhos relative to fermentation form the basis of overflow metabolism in the bacterium, Es...
متن کاملMacromolecular crowding: biochemical, biophysical, and physiological consequences.
CONTENTS PERSPECTIVES AND OVERVIEW ........................................................................................ 28 Nomenclature ........................................................................................................... 30 THEORETICAL CONCEPTS ............................................................................................... 31 The Effect of Macromolecul...
متن کاملImpact of macromolecular crowding on DNA replication
Enzymatic activities in vivo occur in a crowded environment composed of many macromolecules. This environment influences DNA replication by increasing the concentration of the constituents, desolvation, decreasing the degrees of freedom for diffusion and hopping of proteins onto DNA, and enhancing binding equilibria and catalysis. However, the effect of macromolecular crowding on protein struct...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2006
ISSN: 0960-9822
DOI: 10.1016/j.cub.2006.03.047